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Pathology means “the study of disease,” and pathologists are the doctors who interpret biopsy or cytology specimens, monitor laboratory testing, and help interpret those laboratory tests. At HSS the Department of Pathology and Laboratory Medicine is divided into two sections: clinical pathology and anatomic pathology.

Clinical Pathology is responsible for tests performed from blood, urine, and other body fluids. We perform close to 2 million laboratory tests per year in the sections of clinical chemistry, hematology, microbiology, immunology, and immunohematology (blood banking).

Anatomic pathology refers to testing of tissue specimens – at HSS this means the examination of bone, joints, tendons, ligaments, and muscle under the microscope. Our pathology faculty members interpret more than 25,000 anatomic pathology examinations per year, mostly related to metabolic, infectious, traumatic, degenerative, and neoplastic diseases of bones and joints. We also help document mechanisms of success and failure of reconstructive orthopedic procedures, such as joint arthroplasty or enhanced fracture healing. As specialists in musculoskeletal pathology, we also receive consultation cases from patients and pathologists from around the world.

  • Anatomic Pathology: This branch deals with the examination of tissues, organs, and cells to diagnose diseases, particularly through techniques like microscopy and autopsies.

  • Clinical Pathology: Clinical pathologists analyze bodily fluids, such as blood and urine, to diagnose and monitor diseases. They often work closely with laboratory tests.

  • Surgical Pathology: Surgeons often rely on surgical pathologists to provide real-time assessments of tissues and organs during surgical procedures to guide treatment decisions.

  • Forensic Pathology: Forensic pathologists investigate the cause and manner of death in cases of sudden, unexpected, or suspicious deaths, often working with law enforcement.

  • Cytopathology: Cytopathologists study individual cells obtained from various bodily fluids or tissues to diagnose diseases like cancer through methods like Pap smears.

  • Neuropathology: Neuropathologists specialize in the study of diseases of the nervous system, including the brain and spinal cord, to diagnose conditions like Alzheimer’s disease or brain tumors.

Daniel Arber, MD, chair of the Department of Pathology at the University of Chicago Medicine, is one of two UChicago Medicine pathologists (out of three total) named to Chicago magazine’s 2018

Pathology is the study of disease. It is the bridge between science and medicine. It underpins every aspect of patient care, from diagnostic testing and treatment advice to using cutting-edge genetic technologies and preventing disease. Doctors and scientists working in pathology are experts in illness and disease. Pathology (from the Greek word pathología, meaning the study of suffering) refers to the specialty of medical science concerned with the cause, development, structural/functional changes, and natural history associated with diseases.

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